283209

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2620306..2620868 Replicon chromosome
Accession NZ_CP126942
Organism Escherichia coli O1:K1:H7 strain APEC E18006

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag QQA29_RS12890 Protein ID WP_000605675.1
Coordinates 2620306..2620584 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag QQA29_RS12895 Protein ID WP_000781370.1
Coordinates 2620584..2620868 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA29_RS12865 (2615894) 2615894..2616325 - 432 WP_000152310.1 peroxiredoxin OsmC -
QQA29_RS12870 (2616670) 2616670..2616885 + 216 WP_000495766.1 biofilm-dependent modulation protein -
QQA29_RS12875 (2616987) 2616987..2617124 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
QQA29_RS12880 (2617280) 2617280..2618977 + 1698 WP_000433462.1 malate dehydrogenase -
QQA29_RS12885 (2619110) 2619110..2620120 + 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
QQA29_RS12890 (2620306) 2620306..2620584 + 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QQA29_RS12895 (2620584) 2620584..2620868 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
QQA29_RS12900 (2621097) 2621097..2621750 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
QQA29_RS12905 (2621743) 2621743..2622627 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -
QQA29_RS12910 (2622640) 2622640..2625687 - 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T283209 WP_000605675.1 NZ_CP126942:2620306-2620584 [Escherichia coli O1:K1:H7]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT283209 WP_000781370.1 NZ_CP126942:2620584-2620868 [Escherichia coli O1:K1:H7]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CUG6

References