Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2089787..2090289 Replicon chromosome
Accession NZ_CP126942
Organism Escherichia coli O1:K1:H7 strain APEC E18006

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0H2Z0A6
Locus tag QQA29_RS10220 Protein ID WP_000767826.1
Coordinates 2090035..2090289 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QQA29_RS10215 Protein ID WP_001259255.1
Coordinates 2089787..2090038 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA29_RS10195 (2084974) 2084974..2086041 - 1068 WP_000080128.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QQA29_RS10200 (2086041) 2086041..2087111 - 1071 WP_000108997.1 histidinol-phosphate transaminase -
QQA29_RS10205 (2087108) 2087108..2088412 - 1305 WP_001350692.1 histidinol dehydrogenase -
QQA29_RS10210 (2088418) 2088418..2089317 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QQA29_RS10215 (2089787) 2089787..2090038 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QQA29_RS10220 (2090035) 2090035..2090289 + 255 WP_000767826.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QQA29_RS10225 (2090372) 2090372..2091196 + 825 WP_000754737.1 SDR family oxidoreductase -
QQA29_RS10230 (2091242) 2091242..2092171 + 930 WP_000803363.1 LysR substrate-binding domain-containing protein -
QQA29_RS10235 (2092386) 2092386..2092448 + 63 WP_010723108.1 membrane protein YoeI -
QQA29_RS10240 (2092438) 2092438..2093796 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
QQA29_RS10245 (2093975) 2093975..2095033 + 1059 WP_000492334.1 thiosulfate utilization transporter TsuA/YeeE -
QQA29_RS10250 (2095047) 2095047..2095274 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10195.64 Da        Isoelectric Point: 8.0353

>T283203 WP_000767826.1 NZ_CP126942:2090035-2090289 [Escherichia coli O1:K1:H7]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRIIEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT283203 WP_001259255.1 NZ_CP126942:2089787-2090038 [Escherichia coli O1:K1:H7]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z0A6

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References