Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4920121..4920723 Replicon chromosome
Accession NZ_CP126940
Organism Escherichia coli O2:K1:H7 strain APEC E18055

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QQA30_RS24315 Protein ID WP_000897302.1
Coordinates 4920412..4920723 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QQA30_RS24310 Protein ID WP_000356397.1
Coordinates 4920121..4920411 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA30_RS24285 (4916194) 4916194..4917096 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QQA30_RS24290 (4917093) 4917093..4917728 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QQA30_RS24295 (4917725) 4917725..4918654 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
QQA30_RS24300 (4918870) 4918870..4919088 - 219 WP_001314326.1 CopG family transcriptional regulator -
QQA30_RS24305 (4919484) 4919484..4919762 - 279 WP_001296612.1 hypothetical protein -
QQA30_RS24310 (4920121) 4920121..4920411 - 291 WP_000356397.1 NadS family protein Antitoxin
QQA30_RS24315 (4920412) 4920412..4920723 - 312 WP_000897302.1 hypothetical protein Toxin
QQA30_RS24320 (4920952) 4920952..4921860 + 909 WP_001331553.1 alpha/beta hydrolase -
QQA30_RS24325 (4921924) 4921924..4922865 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QQA30_RS24330 (4922910) 4922910..4923347 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QQA30_RS24335 (4923344) 4923344..4924216 - 873 WP_000920754.1 virulence factor BrkB family protein -
QQA30_RS24340 (4924210) 4924210..4924809 - 600 WP_001314324.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T283188 WP_000897302.1 NZ_CP126940:c4920723-4920412 [Escherichia coli O2:K1:H7]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT283188 WP_000356397.1 NZ_CP126940:c4920411-4920121 [Escherichia coli O2:K1:H7]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References