Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2065636..2066138 Replicon chromosome
Accession NZ_CP126940
Organism Escherichia coli O2:K1:H7 strain APEC E18055

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QQA30_RS10280 Protein ID WP_000767822.1
Coordinates 2065884..2066138 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QQA30_RS10275 Protein ID WP_001259255.1
Coordinates 2065636..2065887 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA30_RS10250 (2060814) 2060814..2061881 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QQA30_RS10255 (2061881) 2061881..2062951 - 1071 WP_000108943.1 histidinol-phosphate transaminase -
QQA30_RS10260 (2062948) 2062948..2064252 - 1305 WP_001617113.1 histidinol dehydrogenase -
QQA30_RS10265 (2064258) 2064258..2065157 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QQA30_RS10270 (2065303) 2065303..2065353 - 51 WP_001364200.1 his operon leader peptide -
QQA30_RS10275 (2065636) 2065636..2065887 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QQA30_RS10280 (2065884) 2065884..2066138 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QQA30_RS10285 (2066221) 2066221..2067045 + 825 WP_000754733.1 SDR family oxidoreductase -
QQA30_RS10290 (2067091) 2067091..2068020 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QQA30_RS10295 (2068235) 2068235..2068297 + 63 WP_010723108.1 membrane protein YoeI -
QQA30_RS10300 (2068287) 2068287..2069645 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T283173 WP_000767822.1 NZ_CP126940:2065884-2066138 [Escherichia coli O2:K1:H7]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT283173 WP_001259255.1 NZ_CP126940:2065636-2065887 [Escherichia coli O2:K1:H7]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References