283168

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4689381..4689983 Replicon chromosome
Accession NZ_CP126937
Organism Escherichia coli O2:K1:H4 strain APEC E19019

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QQA31_RS22800 Protein ID WP_000897302.1
Coordinates 4689672..4689983 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QQA31_RS22795 Protein ID WP_000356397.1
Coordinates 4689381..4689671 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA31_RS22770 (4685454) 4685454..4686356 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QQA31_RS22775 (4686353) 4686353..4686988 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QQA31_RS22780 (4686985) 4686985..4687914 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
QQA31_RS22785 (4688130) 4688130..4688348 - 219 WP_001314326.1 CopG family transcriptional regulator -
QQA31_RS22790 (4688744) 4688744..4689022 - 279 WP_001296612.1 hypothetical protein -
QQA31_RS22795 (4689381) 4689381..4689671 - 291 WP_000356397.1 NadS family protein Antitoxin
QQA31_RS22800 (4689672) 4689672..4689983 - 312 WP_000897302.1 hypothetical protein Toxin
QQA31_RS22805 (4690212) 4690212..4691120 + 909 WP_001331553.1 alpha/beta hydrolase -
QQA31_RS22810 (4691184) 4691184..4692125 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QQA31_RS22815 (4692170) 4692170..4692607 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QQA31_RS22820 (4692604) 4692604..4693476 - 873 WP_000920762.1 virulence factor BrkB family protein -
QQA31_RS22825 (4693470) 4693470..4694069 - 600 WP_001314324.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T283168 WP_000897302.1 NZ_CP126937:c4689983-4689672 [Escherichia coli O2:K1:H4]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT283168 WP_000356397.1 NZ_CP126937:c4689671-4689381 [Escherichia coli O2:K1:H4]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References