Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2507030..2507592 Replicon chromosome
Accession NZ_CP126937
Organism Escherichia coli O2:K1:H4 strain APEC E19019

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag QQA31_RS12185 Protein ID WP_000605675.1
Coordinates 2507030..2507308 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag QQA31_RS12190 Protein ID WP_000781370.1
Coordinates 2507308..2507592 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA31_RS12160 (2502617) 2502617..2503048 - 432 WP_000152310.1 peroxiredoxin OsmC -
QQA31_RS12165 (2503393) 2503393..2503608 + 216 WP_000495766.1 biofilm-dependent modulation protein -
QQA31_RS12170 (2503710) 2503710..2503847 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
QQA31_RS12175 (2504003) 2504003..2505700 + 1698 WP_000433462.1 malate dehydrogenase -
QQA31_RS12180 (2505834) 2505834..2506844 + 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
QQA31_RS12185 (2507030) 2507030..2507308 + 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QQA31_RS12190 (2507308) 2507308..2507592 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
QQA31_RS12195 (2507821) 2507821..2508474 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
QQA31_RS12200 (2508467) 2508467..2509351 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -
QQA31_RS12205 (2509364) 2509364..2512411 - 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T283157 WP_000605675.1 NZ_CP126937:2507030-2507308 [Escherichia coli O2:K1:H4]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT283157 WP_000781370.1 NZ_CP126937:2507308-2507592 [Escherichia coli O2:K1:H4]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References