Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1983787..1984289 Replicon chromosome
Accession NZ_CP126937
Organism Escherichia coli O2:K1:H4 strain APEC E19019

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag QQA31_RS09525 Protein ID WP_000767829.1
Coordinates 1984035..1984289 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QQA31_RS09520 Protein ID WP_001259255.1
Coordinates 1983787..1984038 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA31_RS09495 1978965..1980032 - 1068 WP_001513846.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QQA31_RS09500 1980032..1981102 - 1071 WP_016239284.1 histidinol-phosphate transaminase -
QQA31_RS09505 1981099..1982403 - 1305 WP_001513845.1 histidinol dehydrogenase -
QQA31_RS09510 1982409..1983308 - 900 WP_000131789.1 ATP phosphoribosyltransferase -
QQA31_RS09515 1983454..1983504 - 51 WP_071593552.1 his operon leader peptide -
QQA31_RS09520 1983787..1984038 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QQA31_RS09525 1984035..1984289 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QQA31_RS09530 1984372..1985196 + 825 WP_000754737.1 SDR family oxidoreductase -
QQA31_RS09535 1985242..1986171 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
QQA31_RS09540 1986386..1986448 + 63 WP_010723108.1 membrane protein YoeI -
QQA31_RS09545 1986438..1987796 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
QQA31_RS09550 1987975..1989033 + 1059 WP_000492340.1 thiosulfate utilization transporter TsuA/YeeE -
QQA31_RS09555 1989047..1989274 + 228 WP_083574903.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T283150 WP_000767829.1 NZ_CP126937:1984035-1984289 [Escherichia coli O2:K1:H4]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT283150 WP_001259255.1 NZ_CP126937:1983787-1984038 [Escherichia coli O2:K1:H4]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References