283150

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1983787..1984289 Replicon chromosome
Accession NZ_CP126937
Organism Escherichia coli O2:K1:H4 strain APEC E19019

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag QQA31_RS09525 Protein ID WP_000767829.1
Coordinates 1984035..1984289 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QQA31_RS09520 Protein ID WP_001259255.1
Coordinates 1983787..1984038 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA31_RS09495 (1978965) 1978965..1980032 - 1068 WP_001513846.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QQA31_RS09500 (1980032) 1980032..1981102 - 1071 WP_016239284.1 histidinol-phosphate transaminase -
QQA31_RS09505 (1981099) 1981099..1982403 - 1305 WP_001513845.1 histidinol dehydrogenase -
QQA31_RS09510 (1982409) 1982409..1983308 - 900 WP_000131789.1 ATP phosphoribosyltransferase -
QQA31_RS09515 (1983454) 1983454..1983504 - 51 WP_071593552.1 his operon leader peptide -
QQA31_RS09520 (1983787) 1983787..1984038 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QQA31_RS09525 (1984035) 1984035..1984289 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QQA31_RS09530 (1984372) 1984372..1985196 + 825 WP_000754737.1 SDR family oxidoreductase -
QQA31_RS09535 (1985242) 1985242..1986171 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
QQA31_RS09540 (1986386) 1986386..1986448 + 63 WP_010723108.1 membrane protein YoeI -
QQA31_RS09545 (1986438) 1986438..1987796 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
QQA31_RS09550 (1987975) 1987975..1989033 + 1059 WP_000492340.1 thiosulfate utilization transporter TsuA/YeeE -
QQA31_RS09555 (1989047) 1989047..1989274 + 228 WP_083574903.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T283150 WP_000767829.1 NZ_CP126937:1984035-1984289 [Escherichia coli O2:K1:H4]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT283150 WP_001259255.1 NZ_CP126937:1983787-1984038 [Escherichia coli O2:K1:H4]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References