Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2887178..2887871 Replicon chromosome
Accession NZ_CP126934
Organism Escherichia coli O78:H4 strain APEC E19057

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QQA26_RS14440 Protein ID WP_000415584.1
Coordinates 2887575..2887871 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QQA26_RS14435 Protein ID WP_000650107.1
Coordinates 2887178..2887573 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA26_RS14425 (2883042) 2883042..2885300 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
QQA26_RS14430 (2885438) 2885438..2887045 - 1608 WP_001701096.1 ABC transporter substrate-binding protein -
QQA26_RS14435 (2887178) 2887178..2887573 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QQA26_RS14440 (2887575) 2887575..2887871 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QQA26_RS14445 (2888076) 2888076..2888558 - 483 WP_000183494.1 GyrI-like domain-containing protein -
QQA26_RS14450 (2888611) 2888611..2889003 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QQA26_RS14455 (2889155) 2889155..2889814 + 660 WP_001221491.1 quorum sensing response regulator transcription factor QseB -
QQA26_RS14460 (2889811) 2889811..2891160 + 1350 WP_000673406.1 quorum sensing histidine kinase QseC -
QQA26_RS14465 (2891270) 2891270..2891851 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QQA26_RS14470 (2891882) 2891882..2892196 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T283124 WP_000415584.1 NZ_CP126934:c2887871-2887575 [Escherichia coli O78:H4]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT283124 WP_000650107.1 NZ_CP126934:c2887573-2887178 [Escherichia coli O78:H4]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References