Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4927399..4928001 Replicon chromosome
Accession NZ_CP126931
Organism Escherichia coli O78:H51 strain APEC E19025

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QQA25_RS24075 Protein ID WP_000897305.1
Coordinates 4927690..4928001 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QQA25_RS24070 Protein ID WP_000356397.1
Coordinates 4927399..4927689 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA25_RS24045 (4923324) 4923324..4924226 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QQA25_RS24050 (4924223) 4924223..4924858 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QQA25_RS24055 (4924855) 4924855..4925784 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QQA25_RS24060 (4926114) 4926114..4926356 - 243 WP_001087409.1 protein YiiF -
QQA25_RS24065 (4926576) 4926576..4926794 - 219 WP_001315930.1 CopG family transcriptional regulator -
QQA25_RS24070 (4927399) 4927399..4927689 - 291 WP_000356397.1 NadS family protein Antitoxin
QQA25_RS24075 (4927690) 4927690..4928001 - 312 WP_000897305.1 hypothetical protein Toxin
QQA25_RS24080 (4928230) 4928230..4929138 + 909 WP_001162704.1 alpha/beta hydrolase -
QQA25_RS24085 (4929202) 4929202..4930143 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QQA25_RS24090 (4930188) 4930188..4930625 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QQA25_RS24095 (4930622) 4930622..4931494 - 873 WP_000920762.1 virulence factor BrkB family protein -
QQA25_RS24100 (4931488) 4931488..4932087 - 600 WP_001295269.1 glucose-1-phosphatase -
QQA25_RS24105 (4932186) 4932186..4932971 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T283100 WP_000897305.1 NZ_CP126931:c4928001-4927690 [Escherichia coli O78:H51]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT283100 WP_000356397.1 NZ_CP126931:c4927689-4927399 [Escherichia coli O78:H51]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References