Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3935386..3935927 Replicon chromosome
Accession NZ_CP126931
Organism Escherichia coli O78:H51 strain APEC E19025

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag QQA25_RS19220 Protein ID WP_000615976.1
Coordinates 3935649..3935927 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag QQA25_RS19215 Protein ID WP_000729704.1
Coordinates 3935386..3935646 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA25_RS19190 (3931169) 3931169..3931954 - 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -
QQA25_RS19195 (3931926) 3931926..3933638 + 1713 Protein_3759 flagellar biosynthesis protein FlhA -
QQA25_RS19200 (3933743) 3933743..3934021 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
QQA25_RS19205 (3934014) 3934014..3934370 + 357 WP_001030483.1 type II toxin-antitoxin system HicB family antitoxin -
QQA25_RS19210 (3934427) 3934427..3935200 - 774 WP_148935748.1 C40 family peptidase -
QQA25_RS19215 (3935386) 3935386..3935646 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QQA25_RS19220 (3935649) 3935649..3935927 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QQA25_RS19225 (3936083) 3936083..3936823 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QQA25_RS19230 (3936794) 3936794..3937561 - 768 WP_000333380.1 class II glutamine amidotransferase -
QQA25_RS19235 (3937767) 3937767..3938345 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T283096 WP_000615976.1 NZ_CP126931:3935649-3935927 [Escherichia coli O78:H51]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT283096 WP_000729704.1 NZ_CP126931:3935386-3935646 [Escherichia coli O78:H51]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References