Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 640590..641389 Replicon chromosome
Accession NZ_CP126931
Organism Escherichia coli O78:H51 strain APEC E19025

Toxin (Protein)


Gene name yhaV Uniprot ID F4VJD3
Locus tag QQA25_RS03115 Protein ID WP_000347266.1
Coordinates 640590..641054 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QQA25_RS03120 Protein ID WP_001307405.1
Coordinates 641054..641389 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA25_RS03085 (635591) 635591..636025 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QQA25_RS03090 (636043) 636043..636921 - 879 WP_001315856.1 PTS N-acetylgalactosamine transporter subunit IID -
QQA25_RS03095 (636911) 636911..637690 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QQA25_RS03100 (637701) 637701..638174 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QQA25_RS03105 (638197) 638197..639477 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
QQA25_RS03110 (639726) 639726..640535 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QQA25_RS03115 (640590) 640590..641054 - 465 WP_000347266.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QQA25_RS03120 (641054) 641054..641389 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QQA25_RS03125 (641538) 641538..643109 - 1572 WP_001273741.1 galactarate dehydratase -
QQA25_RS03130 (643484) 643484..644818 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QQA25_RS03135 (644834) 644834..645604 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17841.18 Da        Isoelectric Point: 9.4947

>T283081 WP_000347266.1 NZ_CP126931:c641054-640590 [Escherichia coli O78:H51]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT283081 WP_001307405.1 NZ_CP126931:c641389-641054 [Escherichia coli O78:H51]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836NGD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References