Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4690676..4691278 Replicon chromosome
Accession NZ_CP126928
Organism Escherichia coli O2:K1:H4 strain APEC E12053

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QQA27_RS22895 Protein ID WP_000897302.1
Coordinates 4690967..4691278 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QQA27_RS22890 Protein ID WP_000356397.1
Coordinates 4690676..4690966 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA27_RS22865 (4686749) 4686749..4687651 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QQA27_RS22870 (4687648) 4687648..4688283 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QQA27_RS22875 (4688280) 4688280..4689209 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
QQA27_RS22880 (4689425) 4689425..4689643 - 219 WP_001314326.1 CopG family transcriptional regulator -
QQA27_RS22885 (4690039) 4690039..4690317 - 279 WP_001296612.1 hypothetical protein -
QQA27_RS22890 (4690676) 4690676..4690966 - 291 WP_000356397.1 NadS family protein Antitoxin
QQA27_RS22895 (4690967) 4690967..4691278 - 312 WP_000897302.1 hypothetical protein Toxin
QQA27_RS22900 (4691507) 4691507..4692415 + 909 WP_001331553.1 alpha/beta hydrolase -
QQA27_RS22905 (4692479) 4692479..4693420 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QQA27_RS22910 (4693465) 4693465..4693902 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QQA27_RS22915 (4693899) 4693899..4694771 - 873 WP_000920762.1 virulence factor BrkB family protein -
QQA27_RS22920 (4694765) 4694765..4695364 - 600 WP_001314324.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T283068 WP_000897302.1 NZ_CP126928:c4691278-4690967 [Escherichia coli O2:K1:H4]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT283068 WP_000356397.1 NZ_CP126928:c4690966-4690676 [Escherichia coli O2:K1:H4]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References