Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 5094638..5095240 Replicon chromosome
Accession NZ_CP126926
Organism Escherichia coli O2:K1:H5 strain APEC E19035

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QQA32_RS25080 Protein ID WP_000897302.1
Coordinates 5094929..5095240 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QQA32_RS25075 Protein ID WP_000356397.1
Coordinates 5094638..5094928 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA32_RS25050 (5090711) 5090711..5091613 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QQA32_RS25055 (5091610) 5091610..5092245 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QQA32_RS25060 (5092242) 5092242..5093171 + 930 WP_103433215.1 formate dehydrogenase accessory protein FdhE -
QQA32_RS25065 (5093387) 5093387..5093605 - 219 WP_001314326.1 CopG family transcriptional regulator -
QQA32_RS25070 (5094001) 5094001..5094279 - 279 WP_001296612.1 hypothetical protein -
QQA32_RS25075 (5094638) 5094638..5094928 - 291 WP_000356397.1 NadS family protein Antitoxin
QQA32_RS25080 (5094929) 5094929..5095240 - 312 WP_000897302.1 hypothetical protein Toxin
QQA32_RS25085 (5095469) 5095469..5096377 + 909 WP_001331553.1 alpha/beta hydrolase -
QQA32_RS25090 (5096441) 5096441..5097382 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QQA32_RS25095 (5097427) 5097427..5097864 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QQA32_RS25100 (5097861) 5097861..5098733 - 873 WP_289245793.1 virulence factor BrkB family protein -
QQA32_RS25105 (5098727) 5098727..5099326 - 600 WP_001314324.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T283033 WP_000897302.1 NZ_CP126926:c5095240-5094929 [Escherichia coli O2:K1:H5]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT283033 WP_000356397.1 NZ_CP126926:c5094928-5094638 [Escherichia coli O2:K1:H5]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References