Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 469602..470320 Replicon plasmid unnamed1
Accession NZ_CP126682
Organism Pantoea agglomerans strain FL1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QPJ96_RS20995 Protein ID WP_285088627.1
Coordinates 469602..469913 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QPJ96_RS21000 Protein ID WP_161736331.1
Coordinates 469910..470320 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPJ96_RS20980 (QPJ96_20980) 464857..465996 + 1140 WP_285088624.1 site-specific integrase -
QPJ96_RS20985 (QPJ96_20985) 466014..466586 - 573 WP_161736328.1 lipid IV(A) palmitoyltransferase PagP -
QPJ96_RS20990 (QPJ96_20990) 467030..469252 + 2223 WP_285088626.1 ferric-rhodotorulic acid/ferric-coprogen receptor FhuE -
QPJ96_RS20995 (QPJ96_20995) 469602..469913 + 312 WP_285088627.1 type II toxin-antitoxin system HigB family toxin Toxin
QPJ96_RS21000 (QPJ96_21000) 469910..470320 + 411 WP_161736331.1 helix-turn-helix domain-containing protein Antitoxin
QPJ96_RS21005 (QPJ96_21005) 470434..471279 - 846 WP_285088629.1 VOC family protein -
QPJ96_RS21010 (QPJ96_21010) 471300..472439 - 1140 WP_285088630.1 amidohydrolase -
QPJ96_RS21015 (QPJ96_21015) 472442..473542 - 1101 WP_285088632.1 alkylhydroperoxidase domain protein -
QPJ96_RS21020 (QPJ96_21020) 473539..474546 - 1008 WP_222925728.1 putative FMN-dependent luciferase-like monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla / iroN 1..504646 504646


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Antitoxin HigA

(5-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12162.00 Da        Isoelectric Point: 9.7108

>T283010 WP_285088627.1 NZ_CP126682:469602-469913 [Pantoea agglomerans]
MHVISRVPFDEAGRKHPNAAAALDLLYRHLRQGDFSGPDDLRALYASLDRMKYRAKWWVIDVSGNHLRVIFFADFERSKI
FIKHICTHAEYDKLVKKYREVTE

Download         Length: 312 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15285.25 Da        Isoelectric Point: 4.7755

>AT283010 WP_161736331.1 NZ_CP126682:469910-470320 [Pantoea agglomerans]
MNTEAIRLSNQLAEAVPLLAGSNQRHDYQEALELVEYLIEHEPDNPLVDLLCARIAHYEDNDPAMADFNSRQREISTGPG
VLRVLIEQHNLSLSDFENEIGKKSLVSRILSGDRQLTVSHIRALCARFGLSPSLFF

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References