Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2488316..2488815 Replicon chromosome
Accession NZ_CP126627
Organism Staphylococcus aureus strain 17-21

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag QPR40_RS12380 Protein ID WP_000074044.1
Coordinates 2488316..2488558 (-) Length 81 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag QPR40_RS12385 Protein ID WP_000587618.1
Coordinates 2488558..2488815 (-) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPR40_RS12360 (QPR40_12360) 2483621..2484808 - 1188 WP_000026189.1 MFS transporter -
QPR40_RS12365 (QPR40_12365) 2485204..2485980 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
QPR40_RS12370 (QPR40_12370) 2485973..2486635 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
QPR40_RS12375 (QPR40_12375) 2486883..2487959 - 1077 WP_001076672.1 M42 family metallopeptidase -
QPR40_RS12380 (QPR40_12380) 2488316..2488558 - 243 WP_000074044.1 Txe/YoeB family addiction module toxin Toxin
QPR40_RS12385 (QPR40_12385) 2488558..2488815 - 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QPR40_RS12390 (QPR40_12390) 2489174..2489629 + 456 WP_000732082.1 DUF1307 domain-containing protein -
QPR40_RS12395 (QPR40_12395) 2489797..2491373 - 1577 Protein_2396 FMN-binding glutamate synthase family protein -
QPR40_RS12400 (QPR40_12400) 2491567..2492313 + 747 WP_285144378.1 CPBP family lipoprotein N-acylation protein LnsB -
QPR40_RS12405 (QPR40_12405) 2492551..2493744 - 1194 WP_000675411.1 MFS transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-79)

Antitoxin

(1-68)


Sequences


Toxin        


Download         Length: 81 a.a.        Molecular weight: 9649.18 Da        Isoelectric Point: 10.1469

>T282976 WP_000074044.1 NZ_CP126627:c2488558-2488316 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLILSAWSHYD

Download         Length: 243 bp


Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT282976 WP_000587618.1 NZ_CP126627:c2488815-2488558 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References