Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2429876..2430393 Replicon chromosome
Accession NZ_CP126627
Organism Staphylococcus aureus strain 17-21

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag QPR40_RS12100 Protein ID WP_000113262.1
Coordinates 2429876..2430142 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag QPR40_RS12105 Protein ID WP_000584501.1
Coordinates 2430142..2430393 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPR40_RS12070 (QPR40_12070) 2425295..2425831 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
QPR40_RS12075 (QPR40_12075) 2426065..2426889 - 825 WP_000572040.1 formate/nitrite transporter family protein -
QPR40_RS12080 (QPR40_12080) 2427106..2427288 - 183 WP_000079142.1 hypothetical protein -
QPR40_RS12085 (QPR40_12085) 2427375..2427842 - 468 WP_000153344.1 SRPBCC domain-containing protein -
QPR40_RS12090 (QPR40_12090) 2428028..2429581 - 1554 WP_000727769.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
QPR40_RS12095 (QPR40_12095) 2429770..2429841 - 72 Protein_2336 hypothetical protein -
QPR40_RS12100 (QPR40_12100) 2429876..2430142 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
QPR40_RS12105 (QPR40_12105) 2430142..2430393 - 252 WP_000584501.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QPR40_RS12110 (QPR40_12110) 2430558..2430659 - 102 WP_031774922.1 hypothetical protein -
QPR40_RS12115 (QPR40_12115) 2430666..2431265 - 600 WP_000162813.1 DsbA family protein -
QPR40_RS12120 (QPR40_12120) 2431284..2431646 - 363 WP_000819843.1 DUF4467 domain-containing protein -
QPR40_RS12125 (QPR40_12125) 2431901..2433151 + 1251 WP_154427342.1 FemA/FemB family glycyltransferase FmhA -
QPR40_RS12130 (QPR40_12130) 2433230..2434548 - 1319 Protein_2343 ISL3-like element IS1181 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2433187..2434548 1361


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T282974 WP_000113262.1 NZ_CP126627:c2430142-2429876 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9406.58 Da        Isoelectric Point: 4.3407

>AT282974 WP_000584501.1 NZ_CP126627:c2430393-2430142 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPSNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure

References