Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 13607..14264 | Replicon | plasmid pblaNDM5-S1 |
Accession | NZ_CP126537 | ||
Organism | Citrobacter freundii strain CRNMS1 |
Toxin (Protein)
Gene name | higB | Uniprot ID | U3PDC3 |
Locus tag | QOK75_RS26525 | Protein ID | WP_000270043.1 |
Coordinates | 13914..14264 (-) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | QOK75_RS26520 | Protein ID | WP_000124640.1 |
Coordinates | 13607..13909 (-) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QOK75_RS26470 (QOK75_26470) | 9232..9660 | + | 429 | WP_000591074.1 | hypothetical protein | - |
QOK75_RS26475 (QOK75_26475) | 9717..10076 | + | 360 | WP_000422768.1 | hypothetical protein | - |
QOK75_RS26480 (QOK75_26480) | 10076..10522 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
QOK75_RS26485 (QOK75_26485) | 10519..11037 | + | 519 | WP_000210756.1 | nitrite reductase | - |
QOK75_RS26490 (QOK75_26490) | 11037..11267 | + | 231 | WP_000972663.1 | hypothetical protein | - |
QOK75_RS26495 (QOK75_26495) | 11254..12111 | + | 858 | WP_001167032.1 | hypothetical protein | - |
QOK75_RS26500 (QOK75_26500) | 12137..12325 | + | 189 | WP_001270411.1 | hypothetical protein | - |
QOK75_RS26505 (QOK75_26505) | 12342..12869 | + | 528 | WP_001236377.1 | thermonuclease family protein | - |
QOK75_RS26510 (QOK75_26510) | 12927..13199 | + | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
QOK75_RS26515 (QOK75_26515) | 13287..13580 | + | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
QOK75_RS26520 (QOK75_26520) | 13607..13909 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
QOK75_RS26525 (QOK75_26525) | 13914..14264 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
QOK75_RS26530 (QOK75_26530) | 14427..14975 | + | 549 | WP_001061574.1 | transcriptional regulator | - |
QOK75_RS26535 (QOK75_26535) | 15120..16328 | + | 1209 | WP_001339197.1 | IS4-like element ISVsa5 family transposase | - |
QOK75_RS26540 (QOK75_26540) | 16654..16848 | + | 195 | WP_000343597.1 | hypothetical protein | - |
QOK75_RS26545 (QOK75_26545) | 16859..17230 | + | 372 | WP_000516916.1 | hypothetical protein | - |
QOK75_RS26550 (QOK75_26550) | 17223..17693 | + | 471 | WP_001281821.1 | hypothetical protein | - |
QOK75_RS26555 (QOK75_26555) | 17708..18043 | - | 336 | WP_000683476.1 | hypothetical protein | - |
QOK75_RS26560 (QOK75_26560) | 18140..18628 | + | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
QOK75_RS26565 (QOK75_26565) | 18631..19128 | + | 498 | WP_000062185.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | sul2 / floR / aadA5 / qacE / sul1 / qnrA1 / blaNDM-5 | - | 1..197210 | 197210 | |
- | flank | IS/Tn | - | - | 15120..16328 | 1208 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T282955 WP_000270043.1 NZ_CP126537:c14264-13914 [Citrobacter freundii]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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