Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4814266..4814936 Replicon chromosome
Accession NZ_CP126536
Organism Citrobacter freundii strain CRNMS1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QOK75_RS23845 Protein ID WP_134216415.1
Coordinates 4814634..4814936 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QOK75_RS23840 Protein ID WP_046671375.1
Coordinates 4814266..4814607 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOK75_RS23810 (4809807) 4809807..4810565 + 759 WP_003844769.1 phosphonate C-P lyase system protein PhnK -
QOK75_RS23815 (4810655) 4810655..4811335 + 681 WP_134216417.1 phosphonate C-P lyase system protein PhnL -
QOK75_RS23820 (4811332) 4811332..4812468 + 1137 WP_003031811.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
QOK75_RS23825 (4812471) 4812471..4813025 + 555 WP_003844764.1 ribose 1,5-bisphosphokinase -
QOK75_RS23830 (4813012) 4813012..4813446 + 435 WP_003031809.1 aminoalkylphosphonate N-acetyltransferase -
QOK75_RS23835 (4813455) 4813455..4814213 + 759 WP_134216416.1 phosphonate metabolism protein PhnP -
QOK75_RS23840 (4814266) 4814266..4814607 - 342 WP_046671375.1 HigA family addiction module antitoxin Antitoxin
QOK75_RS23845 (4814634) 4814634..4814936 - 303 WP_134216415.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QOK75_RS23850 (4815092) 4815092..4815421 - 330 WP_003031807.1 DDRRRQL repeat protein YjdP -
QOK75_RS23855 (4815491) 4815491..4817755 - 2265 WP_134216414.1 hybrid sensor histidine kinase/response regulator -
QOK75_RS23860 (4817870) 4817870..4819393 + 1524 WP_003031804.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11835.48 Da        Isoelectric Point: 9.9581

>T282952 WP_134216415.1 NZ_CP126536:c4814936-4814634 [Citrobacter freundii]
MSKSLNIRSFRDTWLEDFFERATSHRKILADIHTALARKLDIINAAVSHRDLRSPPGNRYEELTGKLQEYSSIRVNKQYR
LIFKWVNGKAEDVYLDPHIY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13017.84 Da        Isoelectric Point: 7.2040

>AT282952 WP_046671375.1 NZ_CP126536:c4814607-4814266 [Citrobacter freundii]
MKQATRKPTTVGDILQYEYLEPLGLKINDLAEILHVHRNTVSALVNNNRKLTTDMAFRLAKAFDTSVDFWRNLQAAVDLW
EVENDMRAQEELNRIVSVKDFIAQRNSESKKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References