Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3574146..3574687 Replicon chromosome
Accession NZ_CP126348
Organism Escherichia coli strain NN5

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag QN227_RS17145 Protein ID WP_000615976.1
Coordinates 3574409..3574687 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag QN227_RS17140 Protein ID WP_000729704.1
Coordinates 3574146..3574406 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN227_RS17115 (3569929) 3569929..3570714 - 786 WP_000207589.1 putative lateral flagellar export/assembly protein LafU -
QN227_RS17120 (3570686) 3570686..3572398 + 1713 Protein_3347 flagellar biosynthesis protein FlhA -
QN227_RS17125 (3572503) 3572503..3572781 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
QN227_RS17130 (3572774) 3572774..3573130 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
QN227_RS17135 (3573187) 3573187..3573960 - 774 WP_000543899.1 C40 family peptidase -
QN227_RS17140 (3574146) 3574146..3574406 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QN227_RS17145 (3574409) 3574409..3574687 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QN227_RS17150 (3574843) 3574843..3575583 + 741 WP_033557666.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QN227_RS17155 (3575554) 3575554..3576321 - 768 WP_000333380.1 class II glutamine amidotransferase -
QN227_RS17160 (3576527) 3576527..3577105 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T282906 WP_000615976.1 NZ_CP126348:3574409-3574687 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT282906 WP_000729704.1 NZ_CP126348:3574146-3574406 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References