Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4587951..4588553 Replicon chromosome
Accession NZ_CP126345
Organism Escherichia coli strain DX6

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QN223_RS22475 Protein ID WP_000897305.1
Coordinates 4588242..4588553 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QN223_RS22470 Protein ID WP_000356397.1
Coordinates 4587951..4588241 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN223_RS22445 (4583876) 4583876..4584778 + 903 WP_021580356.1 formate dehydrogenase O subunit beta -
QN223_RS22450 (4584775) 4584775..4585410 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QN223_RS22455 (4585407) 4585407..4586336 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QN223_RS22460 (4586666) 4586666..4586908 - 243 WP_001087409.1 protein YiiF -
QN223_RS22465 (4587128) 4587128..4587346 - 219 WP_141087839.1 CopG family transcriptional regulator -
QN223_RS22470 (4587951) 4587951..4588241 - 291 WP_000356397.1 NadS family protein Antitoxin
QN223_RS22475 (4588242) 4588242..4588553 - 312 WP_000897305.1 hypothetical protein Toxin
QN223_RS22480 (4588782) 4588782..4589690 + 909 WP_001162704.1 alpha/beta hydrolase -
QN223_RS22485 (4589754) 4589754..4590695 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QN223_RS22490 (4590740) 4590740..4591177 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QN223_RS22495 (4591174) 4591174..4592046 - 873 WP_000920762.1 virulence factor BrkB family protein -
QN223_RS22500 (4592040) 4592040..4592639 - 600 WP_001295269.1 glucose-1-phosphatase -
QN223_RS22505 (4592738) 4592738..4593523 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T282889 WP_000897305.1 NZ_CP126345:c4588553-4588242 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT282889 WP_000356397.1 NZ_CP126345:c4588241-4587951 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References