Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3744089..3744630 Replicon chromosome
Accession NZ_CP126345
Organism Escherichia coli strain DX6

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag QN223_RS18510 Protein ID WP_000615976.1
Coordinates 3744352..3744630 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag QN223_RS18505 Protein ID WP_000729704.1
Coordinates 3744089..3744349 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN223_RS18480 (3739872) 3739872..3740657 - 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -
QN223_RS18485 (3740629) 3740629..3742341 + 1713 Protein_3622 flagellar biosynthesis protein FlhA -
QN223_RS18490 (3742446) 3742446..3742724 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
QN223_RS18495 (3742717) 3742717..3743073 + 357 WP_001030483.1 type II toxin-antitoxin system HicB family antitoxin -
QN223_RS18500 (3743130) 3743130..3743903 - 774 WP_000543895.1 C40 family peptidase -
QN223_RS18505 (3744089) 3744089..3744349 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QN223_RS18510 (3744352) 3744352..3744630 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QN223_RS18515 (3744786) 3744786..3745526 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QN223_RS18520 (3745497) 3745497..3746264 - 768 WP_000333380.1 class II glutamine amidotransferase -
QN223_RS18525 (3746470) 3746470..3747048 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T282886 WP_000615976.1 NZ_CP126345:3744352-3744630 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT282886 WP_000729704.1 NZ_CP126345:3744089-3744349 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References