Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 594763..595562 Replicon chromosome
Accession NZ_CP126345
Organism Escherichia coli strain DX6

Toxin (Protein)


Gene name yhaV Uniprot ID F4VJD3
Locus tag QN223_RS02905 Protein ID WP_000347266.1
Coordinates 594763..595227 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QN223_RS02910 Protein ID WP_001307405.1
Coordinates 595227..595562 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN223_RS02875 (589764) 589764..590198 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QN223_RS02880 (590216) 590216..591094 - 879 WP_001315856.1 PTS N-acetylgalactosamine transporter subunit IID -
QN223_RS02885 (591084) 591084..591863 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QN223_RS02890 (591874) 591874..592347 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QN223_RS02895 (592370) 592370..593650 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
QN223_RS02900 (593899) 593899..594708 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QN223_RS02905 (594763) 594763..595227 - 465 WP_000347266.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QN223_RS02910 (595227) 595227..595562 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QN223_RS02915 (595711) 595711..597282 - 1572 WP_001273741.1 galactarate dehydratase -
QN223_RS02920 (597657) 597657..598991 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QN223_RS02925 (599007) 599007..599777 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 594763..606550 11787


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17841.18 Da        Isoelectric Point: 9.4947

>T282870 WP_000347266.1 NZ_CP126345:c595227-594763 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT282870 WP_001307405.1 NZ_CP126345:c595562-595227 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836NGD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References