Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3724002..3724543 Replicon chromosome
Accession NZ_CP126343
Organism Escherichia coli strain DAX4

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag QN220_RS17990 Protein ID WP_000615983.1
Coordinates 3724265..3724543 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag QN220_RS17985 Protein ID WP_000729703.1
Coordinates 3724002..3724262 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN220_RS17965 (3719677) 3719677..3720462 - 786 WP_000207587.1 putative lateral flagellar export/assembly protein LafU -
QN220_RS17970 (3720434) 3720434..3722146 + 1713 Protein_3520 flagellar biosynthesis protein FlhA -
QN220_RS17975 (3722370) 3722370..3722867 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
QN220_RS17980 (3723043) 3723043..3723792 - 750 WP_024192679.1 C40 family peptidase -
QN220_RS17985 (3724002) 3724002..3724262 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QN220_RS17990 (3724265) 3724265..3724543 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QN220_RS17995 (3724699) 3724699..3725439 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QN220_RS18000 (3725410) 3725410..3726177 - 768 WP_000333380.1 class II glutamine amidotransferase -
QN220_RS18005 (3726383) 3726383..3726961 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 3716843..3733108 16265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T282863 WP_000615983.1 NZ_CP126343:3724265-3724543 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT282863 WP_000729703.1 NZ_CP126343:3724002-3724262 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References