Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2442101..2442739 Replicon chromosome
Accession NZ_CP126343
Organism Escherichia coli strain DAX4

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QN220_RS11750 Protein ID WP_000813794.1
Coordinates 2442563..2442739 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QN220_RS11745 Protein ID WP_001270286.1
Coordinates 2442101..2442517 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN220_RS11725 (2437253) 2437253..2438194 - 942 WP_001251304.1 ABC transporter permease -
QN220_RS11730 (2438195) 2438195..2439208 - 1014 WP_153443618.1 ABC transporter ATP-binding protein -
QN220_RS11735 (2439226) 2439226..2440371 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
QN220_RS11740 (2440616) 2440616..2442022 - 1407 WP_153443619.1 PLP-dependent aminotransferase family protein -
QN220_RS11745 (2442101) 2442101..2442517 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QN220_RS11750 (2442563) 2442563..2442739 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QN220_RS11755 (2442961) 2442961..2443191 + 231 WP_000494244.1 YncJ family protein -
QN220_RS11760 (2443283) 2443283..2445244 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QN220_RS11765 (2445317) 2445317..2445853 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QN220_RS11770 (2445945) 2445945..2447120 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2447160..2448308 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T282859 WP_000813794.1 NZ_CP126343:c2442739-2442563 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT282859 WP_001270286.1 NZ_CP126343:c2442517-2442101 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References