Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 733063..733756 Replicon chromosome
Accession NZ_CP126343
Organism Escherichia coli strain DAX4

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QN220_RS03590 Protein ID WP_000415584.1
Coordinates 733063..733359 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QN220_RS03595 Protein ID WP_000650107.1
Coordinates 733361..733756 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN220_RS03555 (728151) 728151..728465 - 315 WP_000958598.1 putative quinol monooxygenase -
QN220_RS03560 (728496) 728496..729077 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QN220_RS03565 (729396) 729396..729728 + 333 WP_000917684.1 DUF2645 family protein -
QN220_RS03570 (729774) 729774..731123 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
QN220_RS03575 (731120) 731120..731779 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
QN220_RS03580 (731931) 731931..732323 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QN220_RS03585 (732376) 732376..732858 + 483 WP_284562160.1 GyrI-like domain-containing protein -
QN220_RS03590 (733063) 733063..733359 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QN220_RS03595 (733361) 733361..733756 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QN220_RS03600 (733889) 733889..735496 + 1608 WP_153443585.1 ABC transporter substrate-binding protein -
QN220_RS03605 (735634) 735634..737892 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T282849 WP_000415584.1 NZ_CP126343:733063-733359 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT282849 WP_000650107.1 NZ_CP126343:733361-733756 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References