Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1543856..1544502 Replicon chromosome
Accession NZ_CP126339
Organism Atlantibacter hermannii strain TL13

Toxin (Protein)


Gene name higB Uniprot ID H5UXB4
Locus tag QN094_RS07120 Protein ID WP_002463190.1
Coordinates 1543856..1544209 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QN094_RS07125 Protein ID WP_220397671.1
Coordinates 1544206..1544502 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN094_RS07110 (QN094_07110) 1539253..1542375 - 3123 WP_165432039.1 MdtB/MuxB family multidrug efflux RND transporter permease subunit -
QN094_RS07115 (QN094_07115) 1542375..1543628 - 1254 WP_284556272.1 MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit -
QN094_RS07120 (QN094_07120) 1543856..1544209 + 354 WP_002463190.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QN094_RS07125 (QN094_07125) 1544206..1544502 + 297 WP_220397671.1 helix-turn-helix transcriptional regulator Antitoxin
QN094_RS07130 (QN094_07130) 1544525..1545877 - 1353 WP_284556440.1 molecular chaperone -
QN094_RS07135 (QN094_07135) 1546009..1546863 + 855 WP_002463186.1 DNA-3-methyladenine glycosylase 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-99)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-88)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13569.72 Da        Isoelectric Point: 10.0566

>T282822 WP_002463190.1 NZ_CP126339:1543856-1544209 [Atlantibacter hermannii]
MTWTVVLTPEFEQWFDKQEAGLQDRINMMITLLEISGPNLGRPHVDTLVGSRYPNMKELRIQYAGEPWRVGFAFNHRQQA
VLLYGGQKTGKKRFYTLLIAQVDAIFARDLARKKETL

Download         Length: 354 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11016.71 Da        Isoelectric Point: 6.4155

>AT282822 WP_220397671.1 NZ_CP126339:1544206-1544502 [Atlantibacter hermannii]
MKTFQEKLAEYSPERRAKIERMAEAFAAENGLPTLREMRAMSQQELAERLGVTQPAVAAIERRGEDIKVSTLKRYAEALG
GELQITIELPEGRKVISL

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H5UXB4

Antitoxin

Source ID Structure

References