Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1902251..1902911 Replicon chromosome
Accession NZ_CP126325
Organism Salmonella enterica subsp. enterica strain HL21

Toxin (Protein)


Gene name higB Uniprot ID A0A3Z1E706
Locus tag QN088_RS08975 Protein ID WP_000269841.1
Coordinates 1902251..1902604 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QN088_RS08980 Protein ID WP_000533827.1
Coordinates 1902609..1902911 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN088_RS08945 (1898321) 1898321..1899076 + 756 WP_023245134.1 multiubiquitin domain-containing protein -
QN088_RS08950 (1899051) 1899051..1899899 + 849 WP_284546275.1 ThiF family adenylyltransferase -
QN088_RS08955 (1899944) 1899944..1900234 + 291 WP_242617175.1 hypothetical protein -
QN088_RS08960 (1900228) 1900228..1900692 + 465 WP_000912782.1 DUF6527 family protein -
QN088_RS08965 (1901069) 1901069..1901536 + 468 WP_000201258.1 hypothetical protein -
QN088_RS08970 (1901536) 1901536..1901754 + 219 WP_161976074.1 cell morphology transcriptional regulator XreR2 -
QN088_RS08975 (1902251) 1902251..1902604 + 354 WP_000269841.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QN088_RS08980 (1902609) 1902609..1902911 + 303 WP_000533827.1 XRE family transcriptional regulator Antitoxin
QN088_RS08985 (1903417) 1903417..1904301 + 885 WP_284546276.1 integrase domain-containing protein -
QN088_RS08990 (1905170) 1905170..1906432 - 1263 WP_000058784.1 integrase arm-type DNA-binding domain-containing protein -
QN088_RS09000 (1906770) 1906770..1907567 - 798 WP_000598920.1 DgsA anti-repressor MtfA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1877294..1955453 78159


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13477.35 Da        Isoelectric Point: 9.5699

>T282770 WP_000269841.1 NZ_CP126325:1902251-1902604 [Salmonella enterica subsp. enterica]
VWTIKTTDTFDRWFASLNDTDRVSVLAALLVLREKGPGLSRPYADTVRGSRYSNMKELRIQSRGEPIRAFFAFDPTRTGI
VLCAGNKVGNEKRFYDEMLPVADREFTNWLNTLKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11040.81 Da        Isoelectric Point: 5.7316

>AT282770 WP_000533827.1 NZ_CP126325:1902609-1902911 [Salmonella enterica subsp. enterica]
MGRTLEQLIADEKPEVVAEAQAMATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E706

Antitoxin

Source ID Structure

References