Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4600392..4601146 | Replicon | chromosome |
| Accession | NZ_CP126323 | ||
| Organism | Salmonella enterica subsp. enterica strain CY16 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5RFE2 |
| Locus tag | QN087_RS22300 | Protein ID | WP_000558168.1 |
| Coordinates | 4600392..4600703 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | QN087_RS22305 | Protein ID | WP_001259009.1 |
| Coordinates | 4600700..4601146 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QN087_RS22270 (4596062) | 4596062..4596964 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
| QN087_RS22275 (4596961) | 4596961..4597584 | + | 624 | WP_001747143.1 | formate dehydrogenase cytochrome b556 subunit | - |
| QN087_RS22280 (4597581) | 4597581..4598510 | + | 930 | WP_000027739.1 | formate dehydrogenase accessory protein FdhE | - |
| QN087_RS22285 (4598557) | 4598557..4598847 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| QN087_RS22290 (4598848) | 4598848..4599159 | - | 312 | WP_001159635.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| QN087_RS22295 (4599377) | 4599377..4600306 | + | 930 | WP_000171445.1 | alpha/beta hydrolase | - |
| QN087_RS22300 (4600392) | 4600392..4600703 | + | 312 | WP_000558168.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| QN087_RS22305 (4600700) | 4600700..4601146 | + | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| QN087_RS22310 (4601161) | 4601161..4602102 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| QN087_RS22315 (4602147) | 4602147..4602584 | - | 438 | WP_000560968.1 | D-aminoacyl-tRNA deacylase | - |
| QN087_RS22320 (4602581) | 4602581..4603453 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| QN087_RS22325 (4603447) | 4603447..4604046 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| QN087_RS22330 (4604237) | 4604237..4605040 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| QN087_RS22335 (4605074) | 4605074..4605970 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12324.26 Da Isoelectric Point: 9.3143
>T282763 WP_000558168.1 NZ_CP126323:4600392-4600703 [Salmonella enterica subsp. enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
Download Length: 312 bp
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT282763 WP_001259009.1 NZ_CP126323:4600700-4601146 [Salmonella enterica subsp. enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|