Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4598557..4599159 Replicon chromosome
Accession NZ_CP126323
Organism Salmonella enterica subsp. enterica strain CY16

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag QN087_RS22290 Protein ID WP_001159635.1
Coordinates 4598848..4599159 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QN087_RS22285 Protein ID WP_000362050.1
Coordinates 4598557..4598847 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN087_RS22270 (4596062) 4596062..4596964 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
QN087_RS22275 (4596961) 4596961..4597584 + 624 WP_001747143.1 formate dehydrogenase cytochrome b556 subunit -
QN087_RS22280 (4597581) 4597581..4598510 + 930 WP_000027739.1 formate dehydrogenase accessory protein FdhE -
QN087_RS22285 (4598557) 4598557..4598847 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
QN087_RS22290 (4598848) 4598848..4599159 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
QN087_RS22295 (4599377) 4599377..4600306 + 930 WP_000171445.1 alpha/beta hydrolase -
QN087_RS22300 (4600392) 4600392..4600703 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
QN087_RS22305 (4600700) 4600700..4601146 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
QN087_RS22310 (4601161) 4601161..4602102 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
QN087_RS22315 (4602147) 4602147..4602584 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
QN087_RS22320 (4602581) 4602581..4603453 - 873 WP_000921423.1 virulence factor BrkB family protein -
QN087_RS22325 (4603447) 4603447..4604046 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T282762 WP_001159635.1 NZ_CP126323:c4599159-4598848 [Salmonella enterica subsp. enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT282762 WP_000362050.1 NZ_CP126323:c4598847-4598557 [Salmonella enterica subsp. enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References