Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5324542..5325117 Replicon chromosome
Accession NZ_CP126307
Organism Bosea vestrisii strain A18/4-2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QO058_RS26230 Protein ID WP_284169151.1
Coordinates 5324836..5325117 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag QO058_RS26225 Protein ID WP_152017440.1
Coordinates 5324542..5324823 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QO058_RS26205 (QO058_26205) 5319639..5320997 + 1359 WP_284169145.1 homogentisate 1,2-dioxygenase -
QO058_RS26210 (QO058_26210) 5321270..5322355 - 1086 WP_284169146.1 TRAP transporter substrate-binding protein DctP -
QO058_RS26215 (QO058_26215) 5322418..5323431 + 1014 WP_284169147.1 fumarylacetoacetate hydrolase family protein -
QO058_RS26220 (QO058_26220) 5323579..5324535 + 957 WP_284169149.1 MBL fold metallo-hydrolase -
QO058_RS26225 (QO058_26225) 5324542..5324823 - 282 WP_152017440.1 HigA family addiction module antitoxin Antitoxin
QO058_RS26230 (QO058_26230) 5324836..5325117 - 282 WP_284169151.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QO058_RS26235 (QO058_26235) 5325165..5326733 + 1569 WP_284169152.1 FAD-dependent oxidoreductase -
QO058_RS26240 (QO058_26240) 5326748..5326951 + 204 WP_284173029.1 DUF2783 domain-containing protein -
QO058_RS26245 (QO058_26245) 5326986..5327519 + 534 WP_284169153.1 hypothetical protein -
QO058_RS26250 (QO058_26250) 5327522..5327914 + 393 WP_284169154.1 lysozyme inhibitor LprI family protein -
QO058_RS26255 (QO058_26255) 5327981..5328523 - 543 WP_284169155.1 GNAT family N-acetyltransferase -
QO058_RS26260 (QO058_26260) 5328638..5329156 + 519 WP_284169156.1 CreA family protein -
QO058_RS26265 (QO058_26265) 5329144..5329839 + 696 WP_284169157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-66)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10728.26 Da        Isoelectric Point: 8.5416

>T282743 WP_284169151.1 NZ_CP126307:c5325117-5324836 [Bosea vestrisii]
MILGFADRDTERLFRGEACAARWRAIERIALRKLDMLDAAVTVSDLRSPPGNRLEALKGDRKGQWSIRINDQWRLCFRWS
GDGPEAVQIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10509.88 Da        Isoelectric Point: 7.4033

>AT282743 WP_152017440.1 NZ_CP126307:c5324823-5324542 [Bosea vestrisii]
MARVRTHPGEILREEYLEPLGMSARALAKALDVPGNRISDILRQRRDVSADTAIRLGRFFGTDPRFWLNLQTAHDLSKAE
TEQDYSAIHPHAA

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References