Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1430854..1431456 Replicon chromosome
Accession NZ_CP126166
Organism Salmonella enterica subsp. enterica strain CRSE-01

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag NED09_RS06845 Protein ID WP_001159635.1
Coordinates 1431145..1431456 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NED09_RS06840 Protein ID WP_000362050.1
Coordinates 1430854..1431144 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NED09_RS06825 (1428347) 1428347..1429249 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
NED09_RS06830 (1429246) 1429246..1429881 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NED09_RS06835 (1429878) 1429878..1430807 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
NED09_RS06840 (1430854) 1430854..1431144 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NED09_RS06845 (1431145) 1431145..1431456 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NED09_RS06850 (1431674) 1431674..1432603 + 930 WP_001127705.1 alpha/beta hydrolase -
NED09_RS06855 (1432689) 1432689..1433000 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
NED09_RS06860 (1432997) 1432997..1433443 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
NED09_RS06865 (1433458) 1433458..1434399 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NED09_RS06870 (1434444) 1434444..1434881 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
NED09_RS06875 (1434878) 1434878..1435750 - 873 WP_000921423.1 virulence factor BrkB family protein -
NED09_RS06880 (1435744) 1435744..1436343 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T282707 WP_001159635.1 NZ_CP126166:c1431456-1431145 [Salmonella enterica subsp. enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT282707 WP_000362050.1 NZ_CP126166:c1431144-1430854 [Salmonella enterica subsp. enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References