282692

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4487948..4488550 Replicon chromosome
Accession NZ_CP126140
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain DSE06

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag QNM21_RS21790 Protein ID WP_001159635.1
Coordinates 4488239..4488550 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QNM21_RS21785 Protein ID WP_000362050.1
Coordinates 4487948..4488238 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNM21_RS21770 (4485441) 4485441..4486343 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
QNM21_RS21775 (4486340) 4486340..4486975 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
QNM21_RS21780 (4486972) 4486972..4487901 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
QNM21_RS21785 (4487948) 4487948..4488238 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
QNM21_RS21790 (4488239) 4488239..4488550 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
QNM21_RS21795 (4488768) 4488768..4489697 + 930 WP_001127705.1 alpha/beta hydrolase -
QNM21_RS21800 (4489783) 4489783..4490094 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
QNM21_RS21805 (4490091) 4490091..4490537 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
QNM21_RS21810 (4490552) 4490552..4491493 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
QNM21_RS21815 (4491538) 4491538..4491975 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
QNM21_RS21820 (4491972) 4491972..4492844 - 873 WP_000921423.1 virulence factor BrkB family protein -
QNM21_RS21825 (4492838) 4492838..4493437 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T282692 WP_001159635.1 NZ_CP126140:c4488550-4488239 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT282692 WP_000362050.1 NZ_CP126140:c4488238-4487948 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References