Detailed information of TA system TA282680

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2443488..2443713
• Replicon: chromosome
• Accession: NZ_CP126140
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain DSE06

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: QNM21_RS11875
• Protein ID: WP_000813254.1
• Coordinates: 2443488..2443643 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2443655..2443713 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QNM21_RS11840	2438595..2438876	-	282	WP_000445513.1	phage holin family protein	-
QNM21_RS11845	2438866..2439054	-	189	WP_001688615.1	putative holin	-
QNM21_RS11850	2439048..2439371	-	324	Protein_2322	tellurite/colicin resistance protein	-
QNM21_RS11855	2441542..2442078	-	537	WP_000640113.1	DUF1133 family protein	-
QNM21_RS11860	2442075..2442365	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
QNM21_RS11865	2442365..2442964	-	600	WP_000940751.1	DUF1367 family protein	-
QNM21_RS11870	2443027..2443197	-	171	WP_000734094.1	hypothetical protein	-
QNM21_RS11875	2443488..2443643	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2443655..2443713	+	59	-	-	Antitoxin
QNM21_RS11880	2444070..2445002	+	933	WP_000556390.1	hypothetical protein	-
QNM21_RS11885	2444999..2445553	+	555	WP_001033796.1	hypothetical protein	-
QNM21_RS11890	2445715..2446044	-	330	WP_001676916.1	DUF977 family protein	-
QNM21_RS11895	2446088..2446135	-	48	Protein_2331	hypothetical protein	-
QNM21_RS11900	2446317..2446784	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
QNM21_RS11905	2447169..2447324	+	156	WP_085981757.1	DUF1391 family protein	-
QNM21_RS11910	2447432..2447953	-	522	WP_000004762.1	super-infection exclusion protein B	-
QNM21_RS11915	2448391..2448612	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2438053..2449924	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T282680 WP_000813254.1 NZ_CP126140:c2443643-2443488 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T282680 NZ_CP126140:c2443643-2443488 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT282680 NZ_CP126140:2443655-2443713 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin