282662

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2449588..2450110 Replicon chromosome
Accession NZ_CP126138
Organism Salmonella enterica subsp. enterica serovar Kottbus strain DSK01

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag QNM33_RS12075 Protein ID WP_000221343.1
Coordinates 2449826..2450110 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag QNM33_RS12070 Protein ID WP_000885424.1
Coordinates 2449588..2449836 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNM33_RS12045 (2445569) 2445569..2446270 + 702 Protein_2354 hypothetical protein -
QNM33_RS12050 (2447078) 2447078..2447792 + 715 Protein_2355 helix-turn-helix domain-containing protein -
QNM33_RS12055 (2447848) 2447848..2448756 - 909 WP_010989018.1 hypothetical protein -
QNM33_RS12060 (2448899) 2448899..2449231 - 333 WP_000253154.1 DUF1493 family protein -
QNM33_RS12065 (2449221) 2449221..2449436 - 216 WP_000206207.1 hypothetical protein -
QNM33_RS12070 (2449588) 2449588..2449836 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QNM33_RS12075 (2449826) 2449826..2450110 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QNM33_RS12080 (2450281) 2450281..2450670 + 390 WP_000194089.1 RidA family protein -
QNM33_RS12085 (2450722) 2450722..2451801 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
QNM33_RS12090 (2451994) 2451994..2452482 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
QNM33_RS12095 (2452527) 2452527..2454035 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2444583..2456892 12309


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T282662 WP_000221343.1 NZ_CP126138:2449826-2450110 [Salmonella enterica subsp. enterica serovar Kottbus]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT282662 WP_000885424.1 NZ_CP126138:2449588-2449836 [Salmonella enterica subsp. enterica serovar Kottbus]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References