Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4998318..4998964 Replicon chromosome
Accession NZ_CP126058
Organism Klebsiella pneumoniae subsp. pneumoniae strain CS00491

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag QM175_RS24250 Protein ID WP_016529833.1
Coordinates 4998617..4998964 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag QM175_RS24245 Protein ID WP_002920557.1
Coordinates 4998318..4998617 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM175_RS24225 (4994524) 4994524..4995282 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
QM175_RS24230 (4995332) 4995332..4996162 - 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
QM175_RS24235 (4996213) 4996213..4996542 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
QM175_RS24240 (4996747) 4996747..4998255 + 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
QM175_RS24245 (4998318) 4998318..4998617 - 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
QM175_RS24250 (4998617) 4998617..4998964 - 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QM175_RS24255 (4999130) 4999130..5001577 - 2448 WP_002920561.1 glycogen phosphorylase -
QM175_RS24260 (5001595) 5001595..5003028 - 1434 WP_002920564.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T282539 WP_016529833.1 NZ_CP126058:c4998964-4998617 [Klebsiella pneumoniae subsp. pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT282539 WP_002920557.1 NZ_CP126058:c4998617-4998318 [Klebsiella pneumoniae subsp. pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References