Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2869379..2870068 Replicon chromosome
Accession NZ_CP126058
Organism Klebsiella pneumoniae subsp. pneumoniae strain CS00491

Toxin (Protein)


Gene name higB Uniprot ID A0A331C6E2
Locus tag QM175_RS13765 Protein ID WP_021469727.1
Coordinates 2869751..2870068 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6B0N7G3
Locus tag QM175_RS13760 Protein ID WP_020804705.1
Coordinates 2869379..2869675 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM175_RS13745 (2865771) 2865771..2867153 + 1383 WP_004151222.1 MFS transporter -
QM175_RS13750 (2867197) 2867197..2868813 + 1617 WP_004175961.1 carbohydrate porin -
QM175_RS13755 (2868854) 2868854..2869300 - 447 WP_032435212.1 hypothetical protein -
QM175_RS13760 (2869379) 2869379..2869675 - 297 WP_020804705.1 NadS family protein Antitoxin
QM175_RS13765 (2869751) 2869751..2870068 - 318 WP_021469727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QM175_RS13770 (2870275) 2870275..2870502 - 228 WP_002906690.1 tautomerase PptA -
QM175_RS13775 (2870573) 2870573..2871190 - 618 WP_032425015.1 glutathione S-transferase family protein -
QM175_RS13780 (2871268) 2871268..2872119 - 852 WP_072198177.1 transporter substrate-binding domain-containing protein -
QM175_RS13785 (2872158) 2872158..2872937 - 780 WP_002906697.1 amino acid ABC transporter ATP-binding protein -
QM175_RS13790 (2872921) 2872921..2873847 - 927 WP_032435210.1 amino acid ABC transporter permease -
QM175_RS13795 (2873857) 2873857..2874366 - 510 WP_020802144.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12221.10 Da        Isoelectric Point: 10.2217

>T282533 WP_021469727.1 NZ_CP126058:c2870068-2869751 [Klebsiella pneumoniae subsp. pneumoniae]
MLTFIELQGFSKRRQVLLQDDEFRAFQEILINDPEAGDTISGTGGFRKIRWSRPGMGKRGGVRVIYYNVTKKGRIYLALI
YPKNEQDELNQEQKKMLRQVADLIN

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11057.93 Da        Isoelectric Point: 6.7277

>AT282533 WP_020804705.1 NZ_CP126058:c2869675-2869379 [Klebsiella pneumoniae subsp. pneumoniae]
MKDELFADLLASAEEMVRIEKGEQMLMEQHVHTFSEIDVKAIREATGLKQQDFAAAVGVSYELVKSWETKRRHPTGAARK
LLLLLQGNPLIINLLKVV

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331C6E2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0N7G3

References