Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1959745..1960498 Replicon chromosome
Accession NZ_CP126055
Organism Pasteurella multocida strain P030653/1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QNN13_RS09505 Protein ID WP_015690952.1
Coordinates 1959745..1960071 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QNN13_RS09510 Protein ID WP_015690953.1
Coordinates 1960172..1960498 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNN13_RS09480 (QNN13_09480) 1955050..1955736 + 687 WP_015690949.1 hypothetical protein -
QNN13_RS09485 (QNN13_09485) 1955802..1957331 - 1530 WP_015690950.1 YifB family Mg chelatase-like AAA ATPase -
QNN13_RS09490 (QNN13_09490) 1957439..1958056 - 618 WP_005718080.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
QNN13_RS09495 (QNN13_09495) 1958167..1959036 + 870 WP_015690951.1 VirK/YbjX family protein -
QNN13_RS09500 (QNN13_09500) 1959111..1959587 - 477 WP_005757697.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
QNN13_RS09505 (QNN13_09505) 1959745..1960071 + 327 WP_015690952.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QNN13_RS09510 (QNN13_09510) 1960172..1960498 + 327 WP_015690953.1 HigA family addiction module antitoxin Antitoxin
QNN13_RS09515 (QNN13_09515) 1960552..1962072 - 1521 WP_015690954.1 surface lipoprotein assembly modifier -
QNN13_RS09520 (QNN13_09520) 1962131..1962733 - 603 WP_015690955.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
QNN13_RS09525 (QNN13_09525) 1962820..1963770 - 951 WP_015690956.1 hypothetical protein -
QNN13_RS09530 (QNN13_09530) 1964009..1965043 - 1035 WP_015690957.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12919.76 Da        Isoelectric Point: 9.6705

>T282525 WP_015690952.1 NZ_CP126055:1959745-1960071 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLNDLRSPPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12403.49 Da        Isoelectric Point: 7.2034

>AT282525 WP_015690953.1 NZ_CP126055:1960172-1960498 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKILSIDQHNLLEKIA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References