Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3684704..3685285 Replicon chromosome
Accession NZ_CP125996
Organism Gordonia sp. L191

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag QNM97_RS16670 Protein ID WP_208795107.1
Coordinates 3684704..3684985 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QNM97_RS16675 Protein ID WP_208795105.1
Coordinates 3685001..3685285 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNM97_RS16650 (QNM97_16650) 3680735..3681733 - 999 WP_283819456.1 alpha/beta hydrolase -
QNM97_RS16655 (QNM97_16655) 3681803..3682690 - 888 WP_283819457.1 LysR substrate-binding domain-containing protein -
QNM97_RS16660 (QNM97_16660) 3682716..3683966 - 1251 WP_283819458.1 MFS transporter -
QNM97_RS16665 (QNM97_16665) 3683963..3684601 - 639 WP_283819459.1 GntR family transcriptional regulator -
QNM97_RS16670 (QNM97_16670) 3684704..3684985 + 282 WP_208795107.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QNM97_RS16675 (QNM97_16675) 3685001..3685285 + 285 WP_208795105.1 HigA family addiction module antitoxin Antitoxin
QNM97_RS16680 (QNM97_16680) 3685673..3686818 + 1146 WP_283819460.1 TIGR03364 family FAD-dependent oxidoreductase -
QNM97_RS16685 (QNM97_16685) 3686854..3687537 + 684 WP_283819461.1 phosphonatase-like hydrolase -
QNM97_RS16690 (QNM97_16690) 3687647..3688372 + 726 WP_283819462.1 GntR family transcriptional regulator -
QNM97_RS16695 (QNM97_16695) 3688393..3689589 - 1197 WP_283823231.1 MazG family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-66)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10518.96 Da        Isoelectric Point: 9.0879

>T282518 WP_208795107.1 NZ_CP125996:3684704-3684985 [Gordonia sp. L191]
VIQSFATKDTERVWARKFVPRLGPELTRVAHRKLQALDAAQRLADLASPPGNRLEPLSGDRAGQHSIRVNDQYRLCFTWT
PVGPVDVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10688.14 Da        Isoelectric Point: 5.5882

>AT282518 WP_208795105.1 NZ_CP125996:3685001-3685285 [Gordonia sp. L191]
MPDFEPIHPGETLAADYLPDYGLSQRKLAELIHVPPRRINEIIHGRRAITPDTSIRLGRLFGQSETFWLNMQTRYDLEIA
RATTDVSDITPLAS

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References