Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 794473..795065 Replicon chromosome
Accession NZ_CP125957
Organism Pseudomonas sp. G2-4

Toxin (Protein)


Gene name graT Uniprot ID A0A1K1NRS8
Locus tag QNH97_RS03380 Protein ID WP_072340959.1
Coordinates 794787..795065 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag QNH97_RS03375 Protein ID WP_283555602.1
Coordinates 794473..794778 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH97_RS03355 (QNH97_03355) 791290..791805 + 516 WP_283555599.1 hypothetical protein -
QNH97_RS03360 (QNH97_03360) 792068..792493 + 426 WP_283555600.1 RDD family protein -
QNH97_RS03365 (QNH97_03365) 792678..793622 + 945 WP_283555601.1 hypothetical protein -
QNH97_RS03370 (QNH97_03370) 793707..793979 - 273 WP_092146193.1 hypothetical protein -
QNH97_RS03375 (QNH97_03375) 794473..794778 - 306 WP_283555602.1 HigA family addiction module antitoxin Antitoxin
QNH97_RS03380 (QNH97_03380) 794787..795065 - 279 WP_072340959.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QNH97_RS03385 (QNH97_03385) 795334..797706 - 2373 WP_283555603.1 TonB-dependent siderophore receptor -
QNH97_RS03390 (QNH97_03390) 797828..798811 - 984 WP_283555604.1 FecR domain-containing protein -
QNH97_RS03395 (QNH97_03395) 798798..799313 - 516 WP_283557419.1 sigma-70 family RNA polymerase sigma factor -
QNH97_RS03400 (QNH97_03400) 799498..800007 - 510 WP_283555605.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10464.83 Da        Isoelectric Point: 7.1333

>T282494 WP_072340959.1 NZ_CP125957:c795065-794787 [Pseudomonas sp. G2-4]
MIRSFRCADTQALFETGKTRRWAAILSVAERKLGMLDAAVDLNDLRSPPGNRLEQLYGDREGQHSIRVNGQYRICFVWGA
NGPENVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11133.87 Da        Isoelectric Point: 6.8702

>AT282494 WP_283555602.1 NZ_CP125957:c794778-794473 [Pseudomonas sp. G2-4]
MFKNGMRPVHPGETLKEEYLEPLGLTAAALARALHVSAPTVNDIVLMRRSISADVALRLAAALETSAQFWLNLQTAYDLR
TAEIAKGEQIHREVEKVPHCA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1K1NRS8

Antitoxin

Source ID Structure

References