Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 7883..8532 Replicon plasmid pZM22-1
Accession NZ_CP125948
Organism Comamonas sp. ZM22

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QMY55_RS24570 Protein ID WP_283489073.1
Coordinates 8194..8532 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QMY55_RS24565 Protein ID WP_283489072.1
Coordinates 7883..8197 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMY55_RS24525 (QMY55_24525) 2904..3140 - 237 WP_283489080.1 hypothetical protein -
QMY55_RS24530 (QMY55_24530) 4147..4332 - 186 WP_283489081.1 integrase core domain-containing protein -
QMY55_RS24535 (QMY55_24535) 4553..4897 + 345 WP_283489082.1 hypothetical protein -
QMY55_RS24540 (QMY55_24540) 4906..5526 - 621 WP_283489083.1 hypothetical protein -
QMY55_RS24545 (QMY55_24545) 5528..5899 - 372 WP_283489068.1 hypothetical protein -
QMY55_RS24550 (QMY55_24550) 5912..6265 - 354 WP_283489069.1 hypothetical protein -
QMY55_RS24555 (QMY55_24555) 6274..7185 - 912 WP_283489070.1 ATP-binding protein -
QMY55_RS24560 (QMY55_24560) 7444..7764 + 321 WP_283489071.1 putative addiction module antidote protein -
QMY55_RS24565 (QMY55_24565) 7883..8197 - 315 WP_283489072.1 transcriptional regulator Antitoxin
QMY55_RS24570 (QMY55_24570) 8194..8532 - 339 WP_283489073.1 toxin Toxin
QMY55_RS24575 (QMY55_24575) 8639..8866 + 228 WP_283489074.1 TraY domain-containing protein -
QMY55_RS24580 (QMY55_24580) 8850..9110 + 261 WP_283489075.1 type II toxin-antitoxin system RelE/ParE family toxin -
QMY55_RS24585 (QMY55_24585) 9135..9317 - 183 WP_283489076.1 hypothetical protein -
QMY55_RS24590 (QMY55_24590) 9329..9967 - 639 WP_283489077.1 ParA family partition ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10050 10050


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(45-101)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13117.05 Da        Isoelectric Point: 9.9413

>T282492 WP_283489073.1 NZ_CP125948:c8532-8194 [Comamonas sp. ZM22]
MKAVFVELPAFERNRATYLNDDEFKEFQERLLKNPEAGDMIEGTGGLRKVRHGDPRRGKGTRGGLRVIYYWWSGGPQFWL
FTLYDKDELENLTPKQKAILKQLLKTELEARK

Download         Length: 339 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11711.46 Da        Isoelectric Point: 10.6024

>AT282492 WP_283489072.1 NZ_CP125948:c8197-7883 [Comamonas sp. ZM22]
MTKRDLFAELSEGFDALASARAGKRTLRTHEVELKPEVTITSAELKSIRERLNLSRPVFASYLRTKTRTLENWEQGRAAP
NAQAALLIRLVEKYPDTVSRLAAV

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References