Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2575782..2576299 Replicon chromosome
Accession NZ_CP125903
Organism Staphylococcus aureus strain CHAL1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag QM337_RS12985 Protein ID WP_000251928.1
Coordinates 2575782..2576048 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag QM337_RS12990 Protein ID WP_000584497.1
Coordinates 2576048..2576299 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM337_RS12960 (2570990) 2570990..2571526 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
QM337_RS12965 (2571994) 2571994..2572818 - 825 WP_000594640.1 formate/nitrite transporter family protein -
QM337_RS12970 (2573021) 2573021..2573203 - 183 WP_000079140.1 hypothetical protein -
QM337_RS12975 (2573289) 2573289..2573756 - 468 WP_000153340.1 SRPBCC domain-containing protein -
QM337_RS12980 (2573942) 2573942..2575489 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
QM337_RS12985 (2575782) 2575782..2576048 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
QM337_RS12990 (2576048) 2576048..2576299 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QM337_RS12995 (2576463) 2576463..2576563 - 101 Protein_2517 hypothetical protein -
QM337_RS13000 (2576570) 2576570..2577169 - 600 WP_000162804.1 DsbA family protein -
QM337_RS13005 (2577188) 2577188..2577550 - 363 WP_000819843.1 DUF4467 domain-containing protein -
QM337_RS13010 (2577805) 2577805..2579055 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
QM337_RS13015 (2579152) 2579152..2579883 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
QM337_RS13020 (2579880) 2579880..2580599 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T282481 WP_000251928.1 NZ_CP125903:c2576048-2575782 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT282481 WP_000584497.1 NZ_CP125903:c2576299-2576048 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References