Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 2122315..2122614 Replicon chromosome
Accession NZ_CP125903
Organism Staphylococcus aureus strain CHAL1

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag QM337_RS10525 Protein ID WP_011447039.1
Coordinates 2122438..2122614 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2122315..2122370 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM337_RS10485 2117645..2117905 + 261 WP_001791826.1 hypothetical protein -
QM337_RS10490 2117958..2118308 - 351 WP_000702263.1 complement inhibitor SCIN-A -
QM337_RS10495 2118994..2119443 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
QM337_RS10500 2119538..2119873 - 336 Protein_2032 SH3 domain-containing protein -
QM337_RS10505 2120523..2121014 - 492 WP_000919350.1 staphylokinase -
QM337_RS10510 2121205..2121960 - 756 WP_000861038.1 CHAP domain-containing protein -
QM337_RS10515 2121972..2122226 - 255 WP_000611512.1 phage holin -
QM337_RS10520 2122278..2122385 + 108 WP_001791821.1 hypothetical protein -
- 2122307..2122446 + 140 NuclAT_0 - -
- 2122307..2122446 + 140 NuclAT_0 - -
- 2122307..2122446 + 140 NuclAT_0 - -
- 2122307..2122446 + 140 NuclAT_0 - -
- 2122315..2122370 + 56 - - Antitoxin
QM337_RS10525 2122438..2122614 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
QM337_RS10530 2122723..2123496 - 774 WP_000750406.1 staphylococcal enterotoxin type A -
QM337_RS10535 2123917..2124291 - 375 WP_000340977.1 hypothetical protein -
QM337_RS10540 2124347..2124634 - 288 WP_001040259.1 hypothetical protein -
QM337_RS10545 2124681..2124833 - 153 WP_001153681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / sak / sea / hlb / tsst-1 / groEL 2117958..2185922 67964


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T282474 WP_011447039.1 NZ_CP125903:c2122614-2122438 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 56 bp

>AT282474 NZ_CP125903:2122315-2122370 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References