Detailed information of TA system TA282469

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1628987..1629566
• Replicon: chromosome
• Accession: NZ_CP125903
• Organism: Staphylococcus aureus strain CHAL1

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: QM337_RS07880
• Protein ID: WP_001025401.1
• Coordinates: 1629321..1629566 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1628987..1629352 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QM337_RS07840 (1625730)	1625730..1626287	-	558	WP_000645048.1	DUF2815 family protein	-
QM337_RS07845 (1626313)	1626313..1627479	-	1167	WP_000762530.1	DUF2800 domain-containing protein	-
QM337_RS07850 (1627476)	1627476..1627838	-	363	WP_000985972.1	hypothetical protein	-
QM337_RS07855 (1627853)	1627853..1628176	-	324	WP_000174998.1	hypothetical protein	-
QM337_RS07860 (1628255)	1628255..1628416	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
QM337_RS07865 (1628429)	1628429..1628692	-	264	WP_001124157.1	helix-turn-helix domain-containing protein	-
QM337_RS07870 (1628717)	1628717..1628932	-	216	WP_001097552.1	hypothetical protein	-
QM337_RS07875 (1628987)	1628987..1629352	+	366	WP_001128433.1	hypothetical protein	Antitoxin
QM337_RS07880 (1629321)	1629321..1629566	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
QM337_RS07885 (1629616)	1629616..1629834	-	219	WP_001001383.1	hypothetical protein	-
QM337_RS07890 (1629850)	1629850..1630405	-	556	Protein_1549	phage antirepressor KilAC domain-containing protein	-
QM337_RS07895 (1630431)	1630431..1630658	-	228	WP_001030311.1	hypothetical protein	-
QM337_RS07900 (1630830)	1630830..1631444	+	615	WP_000801423.1	XRE family transcriptional regulator	-
QM337_RS07905 (1631460)	1631460..1632380	+	921	WP_000348133.1	exonuclease domain-containing protein	-
QM337_RS07910 (1632476)	1632476..1632658	+	183	WP_000705240.1	hypothetical protein	-
QM337_RS07915 (1632695)	1632695..1632841	+	147	WP_001795334.1	hypothetical protein	-
QM337_RS07920 (1632838)	1632838..1633452	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	gnd	1590431..1661754	71323

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T282469 WP_001025401.1 NZ_CP125903:c1629566-1629321 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT282469 NZ_CP125903:1628987-1629352 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin