282464

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2434412..2434929 Replicon chromosome
Accession NZ_CP125901
Organism Staphylococcus aureus strain CHAL2

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag QM338_RS12235 Protein ID WP_000113265.1
Coordinates 2434412..2434678 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag QM338_RS12240 Protein ID WP_000584499.1
Coordinates 2434678..2434929 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM338_RS12205 (2429840) 2429840..2430376 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
QM338_RS12210 (2430610) 2430610..2431434 - 825 WP_000572038.1 formate/nitrite transporter family protein -
QM338_RS12215 (2431651) 2431651..2431833 - 183 WP_000230292.1 hypothetical protein -
QM338_RS12220 (2431917) 2431917..2432384 - 468 WP_000153347.1 SRPBCC domain-containing protein -
QM338_RS12225 (2432570) 2432570..2434117 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
QM338_RS12230 (2434306) 2434306..2434377 - 72 Protein_2363 hypothetical protein -
QM338_RS12235 (2434412) 2434412..2434678 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
QM338_RS12240 (2434678) 2434678..2434929 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QM338_RS12245 (2435094) 2435094..2435174 - 81 WP_223197974.1 hypothetical protein -
QM338_RS12250 (2435202) 2435202..2435801 - 600 WP_000162810.1 DsbA family protein -
QM338_RS12255 (2435820) 2435820..2436182 - 363 WP_000819843.1 DUF4467 domain-containing protein -
QM338_RS12260 (2436437) 2436437..2437687 + 1251 WP_283512292.1 FemA/FemB family glycyltransferase FmhA -
QM338_RS12265 (2437784) 2437784..2438515 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
QM338_RS12270 (2438512) 2438512..2439231 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T282464 WP_000113265.1 NZ_CP125901:c2434678-2434412 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT282464 WP_000584499.1 NZ_CP125901:c2434929-2434678 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References