282446

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprA2AS/-
Location 838337..838644 Replicon chromosome
Accession NZ_CP125899
Organism Staphylococcus aureus strain CHAL3

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag QM339_RS04060 Protein ID WP_011447039.1
Coordinates 838337..838513 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 838503..838644 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM339_RS04040 833572..837357 + 3786 Protein_783 phage tail spike protein -
QM339_RS04045 837347..837499 + 153 WP_001153681.1 hypothetical protein -
QM339_RS04050 837546..837833 + 288 WP_001040261.1 hypothetical protein -
QM339_RS04055 837891..838187 + 297 WP_000539688.1 DUF2951 domain-containing protein -
QM339_RS04060 838337..838513 + 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
- 838503..838644 - 142 - - Antitoxin
QM339_RS04070 838725..838979 + 255 WP_000611512.1 phage holin -
QM339_RS04075 838991..839746 + 756 WP_000861038.1 CHAP domain-containing protein -
QM339_RS04080 839937..840428 + 492 WP_000919350.1 staphylokinase -
QM339_RS04085 841078..841413 + 336 Protein_792 SH3 domain-containing protein -
QM339_RS04090 841508..841957 - 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
QM339_RS04095 842642..842992 + 351 WP_000702263.1 complement inhibitor SCIN-A -
QM339_RS04100 843045..843305 - 261 WP_001791826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sak / chp / scn 803361..842992 39631


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T282446 WP_011447039.1 NZ_CP125899:838337-838513 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 142 bp

>AT282446 NZ_CP125899:c838644-838503 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References