Detailed information of TA system TA282444

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 838337..838675
• Replicon: chromosome
• Accession: NZ_CP125899
• Organism: Staphylococcus aureus strain CHAL3

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: QM339_RS04060
• Protein ID: WP_011447039.1
• Coordinates: 838337..838513 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	838501..838675 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QM339_RS04040	833572..837357	+	3786	Protein_783	phage tail spike protein	-
QM339_RS04045	837347..837499	+	153	WP_001153681.1	hypothetical protein	-
QM339_RS04050	837546..837833	+	288	WP_001040261.1	hypothetical protein	-
QM339_RS04055	837891..838187	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
QM339_RS04060	838337..838513	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	838501..838675	-	175	-	-	Antitoxin
QM339_RS04070	838725..838979	+	255	WP_000611512.1	phage holin	-
QM339_RS04075	838991..839746	+	756	WP_000861038.1	CHAP domain-containing protein	-
QM339_RS04080	839937..840428	+	492	WP_000919350.1	staphylokinase	-
QM339_RS04085	841078..841413	+	336	Protein_792	SH3 domain-containing protein	-
QM339_RS04090	841508..841957	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
QM339_RS04095	842642..842992	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
QM339_RS04100	843045..843305	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn	803361..842992	39631

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T282444 WP_011447039.1 NZ_CP125899:838337-838513 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 175 bp

>AT282444 NZ_CP125899:c838675-838501 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin