Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2463991..2464508 Replicon chromosome
Accession NZ_CP125897
Organism Staphylococcus aureus strain CHAL4

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag QM341_RS12490 Protein ID WP_000113262.1
Coordinates 2463991..2464257 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag QM341_RS12495 Protein ID WP_000584499.1
Coordinates 2464257..2464508 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM341_RS12460 (2459417) 2459417..2459953 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
QM341_RS12465 (2460186) 2460186..2461010 - 825 WP_000572040.1 formate/nitrite transporter family protein -
QM341_RS12470 (2461227) 2461227..2461409 - 183 WP_000230294.1 hypothetical protein -
QM341_RS12475 (2461493) 2461493..2461960 - 468 WP_000153344.1 SRPBCC domain-containing protein -
QM341_RS12480 (2462146) 2462146..2463696 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
QM341_RS12485 (2463885) 2463885..2463956 - 72 Protein_2414 hypothetical protein -
QM341_RS12490 (2463991) 2463991..2464257 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
QM341_RS12495 (2464257) 2464257..2464508 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QM341_RS12500 (2464673) 2464673..2464774 - 102 WP_001791744.1 hypothetical protein -
QM341_RS12505 (2464781) 2464781..2465380 - 600 WP_000162813.1 DsbA family protein -
QM341_RS12510 (2465399) 2465399..2465761 - 363 WP_000819843.1 DUF4467 domain-containing protein -
QM341_RS12515 (2466016) 2466016..2467266 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
QM341_RS12520 (2467363) 2467363..2468094 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
QM341_RS12525 (2468091) 2468091..2468810 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T282440 WP_000113262.1 NZ_CP125897:c2464257-2463991 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT282440 WP_000584499.1 NZ_CP125897:c2464508-2464257 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References