282430

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 358370..358677 Replicon chromosome
Accession NZ_CP125897
Organism Staphylococcus aureus strain CHAL4

Toxin (Protein)


Gene name txpA Uniprot ID A0A6B5C9Y4
Locus tag QM341_RS01740 Protein ID WP_072357969.1
Coordinates 358370..358546 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 358538..358677 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM341_RS01720 (353605) 353605..357390 + 3786 WP_031926986.1 phage tail spike protein -
QM341_RS01725 (357380) 357380..357532 + 153 WP_001153681.1 hypothetical protein -
QM341_RS01730 (357579) 357579..357866 + 288 WP_001040254.1 hypothetical protein -
QM341_RS01735 (357924) 357924..358220 + 297 WP_000539688.1 DUF2951 domain-containing protein -
QM341_RS01740 (358370) 358370..358546 + 177 WP_072357969.1 type I toxin-antitoxin system toxin PepG1 Toxin
- (358538) 358538..358677 - 140 NuclAT_1 - Antitoxin
- (358538) 358538..358677 - 140 NuclAT_1 - Antitoxin
- (358538) 358538..358677 - 140 NuclAT_1 - Antitoxin
- (358538) 358538..358677 - 140 NuclAT_1 - Antitoxin
QM341_RS01745 (358599) 358599..358706 - 108 WP_031762631.1 hypothetical protein -
QM341_RS01750 (358758) 358758..359012 + 255 WP_000611512.1 phage holin -
QM341_RS01755 (359024) 359024..359779 + 756 WP_000861038.1 CHAP domain-containing protein -
QM341_RS01760 (360313) 360313..360435 + 123 WP_000346420.1 hypothetical protein -
QM341_RS01765 (360677) 360677..361504 - 828 WP_000136020.1 alpha/beta hydrolase -
QM341_RS01770 (361577) 361577..362776 - 1200 WP_000286484.1 NADH-dependent flavin oxidoreductase -
QM341_RS01775 (362872) 362872..362964 + 93 WP_001801779.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 319336..359779 40443


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6863.47 Da        Isoelectric Point: 10.6777

>T282430 WP_072357969.1 NZ_CP125897:358370-358546 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 140 bp

>AT282430 NZ_CP125897:c358677-358538 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B5C9Y4

Antitoxin

Download structure file

References