Detailed information of TA system TA282428

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 358370..358708
• Replicon: chromosome
• Accession: NZ_CP125897
• Organism: Staphylococcus aureus strain CHAL4

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: QM341_RS01740
• Protein ID: WP_072357969.1
• Coordinates: 358370..358546 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	358534..358708 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QM341_RS01720	353605..357390	+	3786	WP_031926986.1	phage tail spike protein	-
QM341_RS01725	357380..357532	+	153	WP_001153681.1	hypothetical protein	-
QM341_RS01730	357579..357866	+	288	WP_001040254.1	hypothetical protein	-
QM341_RS01735	357924..358220	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
QM341_RS01740	358370..358546	+	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	358534..358708	-	175	-	-	Antitoxin
QM341_RS01750	358758..359012	+	255	WP_000611512.1	phage holin	-
QM341_RS01755	359024..359779	+	756	WP_000861038.1	CHAP domain-containing protein	-
QM341_RS01760	360313..360435	+	123	WP_000346420.1	hypothetical protein	-
QM341_RS01765	360677..361504	-	828	WP_000136020.1	alpha/beta hydrolase	-
QM341_RS01770	361577..362776	-	1200	WP_000286484.1	NADH-dependent flavin oxidoreductase	-
QM341_RS01775	362872..362964	+	93	WP_001801779.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	319336..359779	40443

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T282428 WP_072357969.1 NZ_CP125897:358370-358546 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 175 bp

>AT282428 NZ_CP125897:c358708-358534 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin