Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2461679..2462202 Replicon chromosome
Accession NZ_CP125895
Organism Staphylococcus aureus strain CHAL5

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag QM342_RS12195 Protein ID WP_000074045.1
Coordinates 2461679..2461945 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag QM342_RS12200 Protein ID WP_000587619.1
Coordinates 2461945..2462202 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM342_RS12175 (2456986) 2456986..2458173 - 1188 WP_000026194.1 MFS transporter -
QM342_RS12180 (2458569) 2458569..2459345 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
QM342_RS12185 (2459338) 2459338..2460000 - 663 WP_000923525.1 ATP-binding cassette domain-containing protein -
QM342_RS12190 (2460248) 2460248..2461324 - 1077 WP_001076671.1 M42 family metallopeptidase -
QM342_RS12195 (2461679) 2461679..2461945 - 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
QM342_RS12200 (2461945) 2461945..2462202 - 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QM342_RS12205 (2462562) 2462562..2463017 + 456 WP_000732079.1 DUF1307 domain-containing protein -
QM342_RS12210 (2463185) 2463185..2464762 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
QM342_RS12215 (2464958) 2464958..2465707 + 750 WP_000072465.1 CPBP family lipoprotein N-acylation protein LnsB -
QM342_RS12220 (2465931) 2465931..2467124 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T282427 WP_000074045.1 NZ_CP125895:c2461945-2461679 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT282427 WP_000587619.1 NZ_CP125895:c2462202-2461945 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References